The frames are probably irrelevant, both well over built for the cartridge, but you could compare dimensions.
Generally a SA will have the edge over a DA because of it's swing out crane/cyl. The Single Seven .327 is built on the .22 frame. Not sure about the SP 101.
In any revolver the cyl is the weakest link, specifically when the cyl notches are located over the chambers. Odd # chambers have the advantage in that regard because the notches are located between the chambers. Again, compare dimensions and where the cyl notches are located for a comparative evaluation.
They're likely about equal in strength.