For my way of thinking, if I had to shoot a bad guy I would want him to stop whatever he is doing right now, with as few rounds as possible. I sincerely doubt if anybody, even drug free, without adrenaline pumping will be stopped with one shot from a 22 lr or less than 12.Yeah, mebbe the bad guy will succumb to a wound from a 22 lr at some time, but he will probable be able to take your Bearcat away from you and beat you to death with it.
My personal defense weapon varies between my 9mm with 124 gr JHPs @ 1,150 fps, a 1911 with 200 gr SWC to 1,000 fps, or my 38 Special loaded with 150 gr DEWC to 900+ fps, and I practice with all three...
I'm 72 years old; too young to die and too old to take a whoopin'...