It happened again. Some twit described my .22/250 as "just a varmint rifle" and not a good self defense weapon, which gave me the giggles.. SO: Starting with "varmints" which are defined as animals that are dangerous crops, pets, and domestic food animals. This could describe anything from rabbits, to coyote, to deer. First thought: If it will kill deer, it will kill people. With a muzzle velocity of 3600 to over 4,000 FPS and a flat trajectory it will kill people, and better than a .223, a .556 and probably better than a Nato 7.62. Probably the only creatures for which I wouldn't recommend it is a bear, and elk, or a moose.