When I sent my adjustable sighted bisley vaquero to Ben Forkin we had a long discussion about 5 versus 6 shot 45 Colts on the Ruger frame. Ben said he had done some pretty extensive testing and while the 5 shot could be pushed harder, it came a a pretty high cost in machining and hand slap. I know Lee Martin has a good article on his single action webste aobut 5 shot 45's as well but I know for me a long cylinder 6 shot 45 will do just fine. If I feel like I need more I'll grab the 475 Linebaugh.