Welcome to the site!
Expect what you are about to get into, some semi auto's don't like certain powders and you might be compounding a problem with a 16" barrel.
What is the intended use and do you already have a bullet weight/range already in mind?
I've got an 18" carbine for deer hunting and have been fortunate to quickly find a combination that I can live with, a 150gr RN and a 150gr PSP using BL-C(2). Both giving 3/4" groups at 100 yards but 2" differing points of impact.
I'm also using the same powder in certain .223, 30-30 and 30'06 loads with good results.
If I run into a problem with availability my next powder choices might be Varget or RL15, so far there have been even better reviews of them than BL-C(2).
I'd suggest that you keep on hand some factory ammo of your choice on hand till you arrive at a load that suits you and the firearm, this may help in giving some answers. Also a chronograph would be nice.
The short barrel is expected to produce lower velocities than the published data. For instance the factory 150gr Remington PSP has a published velocity of 2820fps, my 18.5" barrel spits them out at 2630fps average.
The published data in a 24" barrel using 48.0gr of BLC-(2) with a 150gr Nosler BT is 2839fps, the 150gr Remington PSP using the same charge comes out of my barrel averaging 2625fps.
I'm not sure there would be more appreciable velocity loss with a barrel 2" shorter.
Just some things to think about, good luck, let us know what you intend to accomplish with the new baby!