In the last 40 years I have seen 22lr stopped by heavy winter outerwear, jewelry, leather trucker wallets, small books, heavy leather vests (as is REAL motorcycle leathers, not cheap Pakistani black "look at me, I'm a bad man" leather jackets), and once even a skull. The bullet travelled between the skull and the scalp from the back of the head to the forehead before it stopped.
No 22lr (ESPECIALLY out of a short barreled pistol) for me unless there is ABSOLUTELY nothing else available. 380 with a very few loads IMO should be the minimum ever considered... and I would even take a BAD 380 round before a 22lr pistol.