What are you trying to accomplish? Punching paper? Hunting whitetails? I set up my 44 for the latter.
I zero for maximum ordinate (height above line of sight) for around 1 inch. I estimate that range from plugging numbers for the load into a ballistic calculator. Assuming 1000 FPS MV and a 429421ish bullet (BC around .200), I get 50 yds is a good range (hat tip to Dale53). With those figures, I can get POI at 18 yds, which is the depth of the indoor range I use. In this case, it's 3/4 inch high at 18 yds.
Now to a full scale range. Confirm zero at 50 yds, adjusting sights as needed. I'd expect 1 inch high at 30 and 1 inch low at 60 yds and I'd confirm that. I'd expect somewhere around 8-10 inches low at 100 yds. So, I am zeroed out to 60 yds (no adjustment to sight picture). Beyond that, I have to hold over.
If your MV is 950 FPS, the numbers above are close enough to 1000. At 900 FPS, I'd still zero for 50 yds. At the indoor range, I'd adjust for 1 inch high at 18 yds.
If you go with a 2 inch deviation, the numbers change (1.25 in high @18 yds, zero @ 70 yds, 2 in high @ 35 yds, 2 in low @ 80 yds).