Yes, and no. CCI says not to shoot it in a handgun, but I don't know why. If it's CCI, you'll see it printed on the box.
Okay, CCI says this, but it apparently doesn't pertain to a Ruger Single Six convertible:
"Q: I just purchased a box of your part number 0069 and it says 22 WRF, it is not the same size as the 22 Magnum I usually shoot, is this a "short" 22 Magnum?
A: The 22 WRF was a cartridge that was made a number of years ago, the Winchester model 1890 and some others. Shoot those cartridges only in guns so marked, WRF and WMR are different cartridges. While we are on that topic. We advise against the use of 22 WRFin pistols marked for that caliber, as we have found pistols that have small diameter barrels."