A friend of mine had an old 357 Blackhawk that had been a range gun when Bianchi Cup Champion Riley Gilmore had his range in Tulsa. This Blackhawk had many thousands of rounds of dirty range reloads, customer brought in ammo and factory loads shot in it over the years it resided in the range rental cabinet. One day my friend was working the range and they decided to see just how much abuse this old Ruger could put up with.
They locked it in a Ransom Rest, ran a string off the trigger to outside the shooting booth and began running hot loads through it. After about 350 rounds of way too hot loads, it finally cracked the cylinder. They continued firing it and after another 200 ridiculously hot loads it finally locked up. They disassembled it, found a primer backed all the way out of a case blocking the pawl. Reassembled and put another 128 hot rounds through it and a piece of the cylinder popped off the crack.
They stopped shooting it, replaced the cylinder with another and fired it some more. Finally a fair sized piece of the forcing cone broke off and they gave up the abuse.
My friend said they tried that same sort of experiment with a S&W model 19 and locked the cylinder up after only about 30 shots with the same ammo the Blackhawk ate up.
I have seen some old Super Blackhawks with a cylinder exploded over the years, it always makes me cringe to think about how rude that would have been up close when it happened.