In the beginning, the Standard Auto & MKI mags had the follower button on the right side. The frame was marked A-54. When the stamping machine wore out (that made the frames,) it was redesigned a bit, and became the A-100 frame. One of the changes was that the mag follower button was moved to the left side. In the frame, the rounded space had been reversed as well.
To use a later MKI mag in an earlier one, all you did was swap the follower button to the other side. This was by design & to make sure things were efficient for gun owners.
When the MKII came out, there weren't any changes to the dimensions of the later MKI mags, but now the MKII mags could carry 10 rounds. And, you could use MKII mags in all MKI's & Standards, IF you swapped the button for the A-54 frames. Again, good thinking on the part of Ruger engineers.
Next, along came the 22/45, and the introduction of the side mag release button. As such, the angle of the mag was changed, the base pad was changed, AND the addition of a notch & slot to lock in the mag to the release button. This was because the design engineers wanted to replicate a 1911 type gun. None of the 22/45 mags will work in the Standard or MKI's or MKII's.
The MKIII came in with the same mag release as the 22/45, and as such, the MKIII mags have a notch & slot. While I've seen & heard of MKIII mags working in MKII's, MKI's I DO NOT RECOMMEND it as there is the possibility of jamming a mag in the magazine well.
Does this clear it up?