I have been fortunate enough to hunt in Africa twice.
In most African hunting, you will be unlikely to encounter shots over 200 yards. Some of that is due to terrain/habitat and some is due to the fact that the PH will want to get you closer to your game.
In Namibia in 1992 I took a Ruger Ultralight 270 and my Mark X 35 Whelen. I used the 270, with 150gr Nosler Partitions, on blesbok and springbok. Springbok hunting is a lot like pronghorn hunting in wide open country. I did have a 300+ yard shot on my springbok with the 270.
I used the 35 Whelen with 250gr Nosler Partitions for warthog, kudu, gemsbok(2), and hartebeest.
When I went back to Zimbabwe in 1997, I had hoped to hunt buffalo and lion. I took my 35 Whelen and a Win M70 in 375 H&H.
I used my 35 Whelen on sable and waterbuck....
Though I didn't get a lion or buffalo, I did get in a lot of shooting with the 375. In addition to taking a hippo, warthog, impala, and tsessebe with it, I also took quite a few bait animals and meat animals for the ranch owner.....mostly kudu cows and impala. I used the 375 to take 9 different animals on the last day of my hunt.
Here's a very good tsessebbe that took THREE 300gr Swift A-Frames through the chest before giving up the ghost.
For most African hunts, you need a deer rifle and an elk rifle. If I were to plan another trip, I'd probably take my M77RSI in 308 and my 35 Whelen.