IMHO, practical use is limited to areas requiring the unique features designed into the cartridge.
Based on our experience with the 300AAC, terminal performance of larger diameter lower velocity bullets that allow feeding through AR type actions is dismal. At least 1/2 dozen bullet designs purported to be "suitable for medium game" failed to expand and/or transfer energy sufficient to produce effective kills.
Tom related a recent conversation he had in a gun shop he'd visited on one of his travels. Tom was looking through the inventory of 300AAC ammo in the shop and the store employee proceeded to tell him all the great marketing propaganda for the various types. When Tom responded with a series of dismal results from range and actual field use, the gun shop guy seemed confused by the discrepancies. He'd obviously not seen any of the ammo in actual use. Now, I don't expect every shop to test fire every type of ammo they sell, but I do expect the ammo makers to be honest with their claims.