Hi,
I don't load 2400, so I can only relay personal observations:
A buddy uses a lot of it in his .357 Mag and .44 Mag. He uses Keith style bullets from Lyman molds, which are just a hair heavier than "standard" bullets in caliber (e.g. if I'm loading a 158 gr. in my .357 he's got maybe a 165, and where my .44 Mag has a 240 gr., he may have 255 or so.)
After a bit of experimentation w/ lubes, crimps and the actual powder charge, he's found that "sweet spot" and gotten some very accurate and consistent loads (he used them for IHMSA silhouettes for a few years.)
They don't smoke TOO badly or make a huge mess of his stainless guns, but there's still a lot of "residue" that gets blown about every time he pulls the trigger! And that's w/ a brand new jug of 2400.
Rick C