Even though this is a very old thread,, and as noted,, some new folks around,, it's still fun to re-read.
It's quite obvious that everybody has their preferences in what they use for mid-range loads. Some love Unique,, & others hate it. Some love HS-6 & others hate it. It goes back to what I've said often. I let the gun's accuracy decide what I use. Accuracy first,, period. I can clean a gun. I can wipe out unburnt powder. I can work on my crimp to get a better burn rate. I can use powder coated over lubed bullets for less smoke.
But I want the gun to send the bullets where I aim!
Various bullets, primers & powders can give each shooter different results. Then the gun itself can decide if it likes a load or not.
I've been known to test hundreds of rounds in a gun chasing the best accuracy. But once I figure out what a gun prefers,, I stick with that.
I use Unique, HS-6, 2400, 4227, Longshot, Trailboss, Universal, & others often.
Due to my due diligence in studying,, AND the fact I didn't see a need to jump in on a newer powder,, I've never tried "Lil'-gun."
I've heard enough stories to be a bit more cautious about that powder in my revolvers.
If I run out of all my choices,, and it's the only powder available,, I might then give it a try. But the above listed ones I use have served me well for decades.