One difference is about 70 years track record. Single Sixes have been around long enough for us to know that we can shoot dozens of bricks through them and they are still tight and accurate. I have at least a half dozen Single Sixes and they average 50 years old. I bought all of them used. They all have a 0.004" cylinder gap. They look like single actions looked 150 years ago, except for the adjustable sights on some. Some are beat up and freckled but none of them look like they were painted with flat black Rustoleum. Someone told me his new Wrangler had a .007" cylinder gap. That's what my Uberti has and it groups like buckshot. Why would I even consider a Wrangler when there are so many used SS's to be had for a little more? A Single Six in "fair" condition is worth more to me than a new Wrangler because I know the internals are still like new.