Last season I shot 3 deer. For fun I used the 357 Marlin and my #1 RSI/243 on two of the deer. I was also going to use the 223 but decided not to go that small after I used the 243. I had not shoot a deer with either of these cartridges or rifles before. Range was short. Within 50 yards for both animals.
Long story short, I was not all that impressed with the 243. At the impact there was very little reaction from the animal, to the point where I thought I had missed, and no blood trail.

I shot him low on the heart. He trotted off about 50 yards before piling up.
The 357 shot deer was also a heart shot. At impact she jumped and bucked (like I like seeing!) and ran maybe 40 yards before dropping. There was a visible entry wound. Even at fading light 50 yards and no scope. There was also a very good blood trail. The exit wound was uneventful with no blood.
I have two loads worked up for this rifle in 357. The 357 load I shot the deer with was a 158 grain Hornady XPT SP, Federal nickle brass, Winchester small rifle mag primer and Lil'gun powder. Max listed load I could find is with Winchester brass. I reduced a little as max looked a little hard on the primers with the Federal brass. This load chronographs at 1920 fps from my rifle. Shoots well in a 4" S&W too with surprising little flash/blast.
My second load is with the Lyman 358156 bullet. This weighs 165 grains with gas check and lube. Same powder charge/brass/primer and this bullet goes 1820fps from my rifle. I have not had a chance to shoot a deer with this load yet. I will next year..I hope. Another + with this bullet is it is very accurate seated long in 38 special brass.
My "small" rifle experiment/experience, arugably, is limited to two deer. I was very happy with the 357 at 50 yards and plan to use it again.
My advice is to go with Lil'gun in either 180 grain or 158 grain. It gives the highest velocity with lowest pressure. I also tried 2400. I got good velocity but poor accuracy with loads exceeding 1600fps. 296 rendered poor accuracy as well at max loads (frommy rifle).
Hope this helps.
I might add, the 357 sure will spoil a person on recoil. :lol:
Corbi