Well, I happen to own many of the Ruger 45 convertables, including the one you mentioned. My stainless Bisley convertable hasn't had the cylinder reamed yet, and it shoots just fine with lead.
Many folks find that it tightens accuracy by doing mods to any firearm. In the case of the 45 convertables, quite often it's done by reaming the cylinder holes to a uniform .4525. Others add a forcing cone re-cut, changing the angle. (Not always necessary.) And even others do a firelapping of the barrel.
I think too many folks shoot lead not realizing that they need to keep the velicity of the bullet matching the hardness of the bullet. Soft lead, slower, harder lead can be run faster.
I would say that if you are looking at one, do not let these "issues" keep you from getting a fine gun.
And yes, I have heard that Ruger has been cutting the cylinder holes more uniform than in the past.