There are many variables; method of pressure testing, different barrels/guns/fixtures, different components (brass/primers/bullets), different lots of powder, different weather conditions, etc. etc.
The best thing to do is look at as much data as you can and translate that to your situation. Where there is a lot of data there will be generalities that are apparent. With data that is scarce for a particular cartridge select what is a safe starting place, say 10% below a max charge with components that match-up well, and compare the actual shooting with factory ammo to get a feel for what you are working with. A chronograph will give you data points to work with. After that work up a load with your gun being careful to not over-stress anything.
Simple, huh? Your brain and experience will guide you as well as asking friends for help. I think you could start with the newest data from the powder manufacturer as long as it is not way out of line, but that is just me. 8) 8)
...Jimbo