In Kydex, not leather, but is ambidextrous and holds any MkII, Mk IIi or 22/45 with a red dot:
http://www.midwayusa.com/product/429568/tactical-solutions-belt-holster-ambidextrous-ruger-mark-i-mark-ii-mark-iii-22-45-kydex-black
http://www.amazon.com/dp/B005K7ZG0W/?tag=googhydr-20&hvadid=18750471204&hvpos=1t1&hvexid=&hvnetw=s&hvrand=4394135641859253523&hvpone=&hvptwo=&hvqmt=b&ref=pd_sl_8wy286e8ja_b
I'm a lefty and I have one for my 22/45 Mk II and it's very secure. You will have to reverse or shorten the factory Weaver rail to clear but that's easy.