I use a lot of 4227 (my favorite) and I am really happy with it (357mag and max, 44 mag, 45 colt). It is a slower powder like the H110, which uses magnum primers. It is not as hot as H110 and as opposed to H110, it downloads beautifully. I get some residue from 4227, but it cleans easily. The accuracy in a Maximum is what I call outstanding. I REDUCED my recipes and started using magnum primers a couple of years ago. I got a small bump in velocity and the residue was reduced.
I do believe that my hotter 4227 reloads had less left-over residue. However, I didn't like the recoil with those beasts so I keep them medium speeds. The small amount of residue is a non issue. Less than many other powders.