Sorry, don't use speed loaders so can't offer any info there. However, I'm mainly a Smith & Wesson revolver guy, but I'm a huge fan of the Ruger GP100. I have one in stainless steel with the 5" bbl and love it. I think that the 4" bbl is a great do-all-things barrel choice. My GP has a great action, crisp trigger, perfectly timed, couldn't ask for better. They do definitely have a different action feel than the Smith & Wesson, not better, not worse, just different. If it became necessary to sell either my 686 or my GP100, I honestly don't know which one would go. I just don't plan to ever have to make that choice, like them both. You will be very happy with a 4" bbl GP100! :D