Howdy
2.3CC (about 33 grains) Schuetzen FFg under a 250 grain PRS Big Lube soft lead bullet lubed with SPG and sized to .452. Or else 45 Schofield loaded with 1.9CC (about 28.5 grains) Schuetzen FFg under a 200 grain J/P 45-200 Big Lube soft lead bullet lubed with SPG and sized to .452. That's a nice, mild shooting load.
In a pinch, I have been known to use 7.5 grains of Unique under a 250 grain RNFP bullet. Not a barn burner, but not a mouse fart either.