In assumption for "best" rounds say definition is hit the bulls eye easiest, I use standard 38 special. Slow moving, heavy, wadcutter, lead round nose, FMC target, etc,. Good thing is, that gun will handle anything 357 or 38.
357 seems to be harder to find in target ammo at least in my area. But there is plenty of 38+p for defense and normal 38 for target use. I wouldn't feel deficient with any 38 for self protection but there is bigger and better and that gun will handle it.