I think Bear Paw means "New Vaquero" to distinguish from the (original, large frame, larger cylinder) "Vaquero" that was discontinued around 2005.
I would say that if you handload, then get a 45 Colt. If you don't, just keep your handgun cartridges more distilled and stick with a 357 / 44Mag collection.
I own and have loaded for the 45 Colt after getting the big bore itch many years ago, and in my experience, I never enjoyed the level of accuracy from the 45 Colt (whether high or low pressure, jacketed or cast, light or heavy, or even cast fitted to my cylinder throats, etc) compared to the level of accuracy I got from my 44Mag / 44Spl. As a result, over the years, my 45Colt collection dropped off and the 44Mag and 357Mag grew. I have only a few 45Colts left now that are really accurate but many more 44/357. At short distances (10-20yds) and since one's precision expectations can be very subjective, you'll probably be okay. My advice would be to not compare it to your Super Redhawk 44Mag or a 357 from any revolver. But if you wanted to hunt large game at short distances (or for protection), then I'd go with a Ruger-only recipe and 45Colt with hard cast every time in a suitable revolver such as the original Vaquero. BTW, the big bore itch only starts with the 45Colt! There's also the 500 Wyoming Express, 500 Linebaugh, and the 475/480,… not to mention the 454, 460, and 500S&W. If you already have a solid 44Mag and you wanted to step into big bore, I'd look at the Ruger Super Blackhawk Bisley stainless in either 454 or 480 and then start handloading so you can download them for fun. If you're tall, get some thicker wooden grips for the Bisley to keep the back of the trigger guard from busting your knuckle, or as John Linebaugh told me, learn to rotate the grip frame in your hand to turn the knuckle away from the back of the trigger guard. (I preferred to get thicker, hand-filling custom grips.).
Edited for typos