Single 7s do not have Ruger's Reverse Indexing Pawl System like the New Vaqueros and NM Flat Top Blackhawks.
However, because they are a 7 shot, as NikA posted, they are very close. For that reason and because the loading is so tight for the 327 case rims, they all benefit from slightly enlarging the loading gate trough on one side to make the chambers line up.
When sent back to Ruger, they'll fix it for you for free including shipping. However, most people find it simpler to do it themselves. I've done several and it's a vast improvement.This is one of those applications that is perfect for a Dremel tool. You need about a 1/2" grinding bit and one for final polishing. Just don't go too deep at the bottom of the trough or you'll go thru to the inner frame. Not a problem, just unsightly.
I don't know about the Single Ten chamber alignment, I've never owned one. But with ten holes, they might align or can't be far off. If the chambers don't align, it would be even easier to fix the same way as above.