figured I throw in a word or two... I started using the shot loads in 22 lr, 22mag, 38's and 357's in the mid '70's. the 22lr are a bit weak so it may take two. the 22mag are a bit stronger so they work well. the 38's are used in a 2" chief or a 4" 686. the 22mag are out of an old high standard derringer. the 44's are from a 6 1/2" m29 or a 4 5/8" saa. Last big moccasin I had in the back yard was hit twice with the 38's cause he was big and I was close and we had the church youth group (young teens). I sent them in the house and did my job. btw, the 22's are from a 6" k22 so they have a bit of barrel to travel, do not center the shot cause the pattern is a bit like a donut (hole in center, tell that to a bullseye shooter??). the 2" and the 4" are the better lengths to use. I live at a lake in N Texas so I usually do not wonder around with a .410. 0r 20 ga., I slip the pistol in my pocket so it's a little less noticeable by noisy neighbors. last copperhead was in the garage, dropped a 4' length of 4 + 4 lumber. he was too close to shoot, didn't have a gun, did have a piece of lumber though... did buy shot loads in 9mm, 40 s&w and 45 acp but have not used any but the 9, worked good in glock w/ polygonal bore. 40 and 45 are too big in shot size for my tastes. I load my own in 38 and 44 though. I try to keep small shot for that. size 9 shot is almost small enough. 10 - 12 are better. it saturates the area and intensifies the destruction with one shot.