To each his own ideas.
I've had 2 17HM2 rifles(actually just the barrels) but got out of that caliber many years ago. It was a GREAT varmint removal tool. Bullets expanded/fragmented even in smallish critters making it much easier to control in places where a pass through wasn't acceptable. Accuracy was fairly good within the 'need parameters' and noise wasn't excessive. Raccoons, muskrats, and groundhogs were the primary targets.
I can't imagine a real 'need' for this cartridge in a handgun platform. It would lose much of it's effectiveness and be excessively loud in a handgun barrel. Squirrel hunting might be the only viable application as the bullets wouldn't carry as far as a 22lr and would be more likely to disintegrate on a small branch rather than ricochet and head off into somewhere land.