I reload more for 327 than any other caliber I reload for, such as 38 or 357 ect. I have been using my federal brass for probably 15 to 20 loads so far. If I need more brass I'll just buy a box of factory ammo. But the brass is very good, not many crushed or bent cases during reloading. That is me I suppose not the brass, but some brass seems to be very fragile. The Federal 327 is very consistent in size and thickness etc. easy to prime, easy to clean.... Not to discount Starline brass, I have a lot of it in other calibers, it's just that during the past ammo shortage, I could always find 327 on the shelf. And the price is constant ~27 to ~29 per box. But I like small rifle primers and 100 grain poly coated bullets. Check out SNS casting in Illinois. Cheap shipping and very good quality. And as far as powders, I like a few of them HP38, H110 (probably my favorite for this caliber) and CFE is good also. I think each powder has a sweet spot as far as accuracy is concerned. I think overall, my loads are right in the middle, not anemic and not barn burners. For my shooting, that is the accuracy I've found works best.
I've got an 8 shot Blackhawk and an SP101 in 327. Wish I had the GP100, perhaps someday... The Blackhawk has been shot enough the trigger is starting to get really, really nice. In fact the whole gun is slicking up just fine. It's one of my favorites.
Good luck!