I dunno. My dad had a Single-Six convertible, which my brother now holds, and I appreciate the .22WMR cartridge. I see Winchester now makes a PDX1 cartridge. I also like hammers and the option of SA on my DA revolvers. I understand this is Ruger Forum, but Charter Arms offers a 2" Pathfinder in .22WMR for $410 MSRP, more than $100 cheaper than the Ruger. At 19 oz., there'll be a little less recoil; stainless, too. Yeah, I know, there're questions about quality. I would have to hold it in my hand to decide. If and when my wife wants a handgun, however, that's the way I might go.
I'll still carry my 2¾" 9mm Speed-Six, myself. The 4" .38 Special Speed-Six keeps its place in the arsenal, as well.