Well, this is a game that I love. The fact is, what you might think is your best choice may very well not be. In fact I'll post a "game" that will prove this to you if you want t o play.
As for "it depends"....... well, duh. Of course "it depends", that's the entire point of the question if I understand it. It requires an answer that's looking for a compromise.
It you had to choose one and only one handgun caliber, what would it be?
A southern native, I moved west 33 years ago. Things are indeed bigger here and when I prospect in the desert, or spend time in the High Sierra bush I carry a 44 or 45. It gives me an edge vs the bigger critters.
OTOH: my first centerfire handgun was a 4" Ruger 357 Blackhawk. I ki8lled cottonmouth moccasins, wild boar, a black bear (with a single shot), bobcat, and stood off two attacks (a week apart) by the same feral dog pack with that piece. Truly, it got done anything I needed it to do.
The ammo is cheap to buy and/or easy to reload. Its miserly with its component requirements (i.e lead and powder) and in 38 Special guise offers the perfect pocket pistol (i.e S&W J Frames), perfect DA carry revolvers from Ruger or S&W, and the perfect working sixguns, again I refer to the Ruger Blackhawk or Bisley (My Ruger 357 Bisley came from the estate of Skeeter Skelton - who could possibly ask for more
The fact is, factoring all of the "it depends" into the equation, I still believe the best all around, general purpose, overall "utilitarian" handgun caliber is the 357 Magnum. I can load it light enough to do a 22 rimfire's job and heavy enough to kill beasts four-legged or two legged.
But that's just my take on it. Obviously, every person should base his choice on his own experiences and contingency.
That said, I'll continue to pack my 44s and 45s into the bush, they're a better choice in my AO since I don't
have to make that compromise. But make no mistake: if I had to choose one and only one, it'd be the 357 without a second thought!
:wink: