The SR22 gives better ballistics than the LCR due to the longer barrel. and the 3 extra rounds and a second magazine very easy to carry and reload. I like Velocitors for carry and find they give the same or better velocity than stingers in a handgun and they use a full 40 grain bullet. I have never had reliability issues with 22 autos that work well, and that usually means a little bigger gun than a Beretta 21 and the SR22 fits right in there. I don't hesitate to use a 22 as EDC as I believe the chance of me coming into a den of muggers, illegal bikers, or PCP drugged crazies with my rather mundane live style is rather unlikely, and a "road rager" is more likely. For that, "a gun" is what matters and not so much the power of it.
I see the SR22 as 3 "triple taps" with a couple of rounds left over. Three rapid fired rounds of 22lr is very easy to do with the handy little SR22, and mine is accurate and reliable.
At times I go about with nothing by a NAA mini in a pocket, and I see the SR22 as a dramatic step up from that. Of course if I lived the life of many posters on gun discussion boards, and went into dark alleys, biker bars, drug dealing areas and ghettos of cities large and small, I would feel differently. MY first line of personal defense is common sense, the avoidance of trouble, and of NOT going into trouble areas and avoiding the local watering holes that are referred to here in the south as "knife and gun clubs". I also don't respond to instigation on the road or elsewhere and go on about my business.
I am 59 years old and survived 28 years of police work (not the desk type, but the in a police car responding to calls type) in a very congested county of a million or so people in Florida where everyone is armed by going by the above guidelines.
A well made 22 auto pistol does quite nicely for me.