That particular GF is a New Model XR3-RED as it pertains to the
grips, so a YES does answer your first question.
As for Large Frame, Small Frame, when it comes to this ALL grip frames fit Ruger Cylinder Frames from Single Six to Super Blackhawk.....
....Now with that said, The Newer New Model Cylinder frames got a little taller in the rear, so a older grip frame will end up a little short on a Newer NM. (Simple short answer)
Steel, Old Model, skinny trigger hole, XR3-RED grip frame size, NOS so it has enough material to fit it perfect to your Gun & Grips.
This will bolt/screw right up to your cylinder frame with minimal fitting if any required.
It will need the sides, ears, & grips fitted, they were cast slightly larger to allow enough material to get a perfect fit. Then it will need to be blued.
FWIW; I liked to rust blue w/ the laurel mountain brown/blue solution. Turns out real nice and holds up very well.
$115 shipped