I too really liked the 225gr Hornady in the .375Ruger. Kinda like a 150gr in an '06.
Found a superlative accurate load with Reloader15, that's a bit under max.
I keep the rifle in case they clone a T-Rex! Too much except for maybe "Hogzilla".
But it puts deer down RIGHT NOW.
Fortunately I have a good stash of the Speer 235's.