Personal preference I think in this case (I don't hunt, so no comment on terminal ballistics, etc.). We all either have experience with one or another or both, and are minds get 'set in the their ways'. For, me ... its the .45 Colt . Fits me right down to the ground. just as Jim Luke feels the .44Spec and .44Mag is all he needs/wants. I'll pack a medium frame .45C most of the time in the woods, and if I need more (hasn't come up yet), I'll pack my large frame .45C. From what I read from Taffin, Pearce, Linebaugh, Seyfried, Prosac, etc. (guys with extensive hunting experience), the .45C will handle all I ever need.... So there it is..... That said, I still like to shoot the .44Spec, and .357, .32 (recent), and .22, and sometimes the little brother .429 Mag. Each has a use ... with much overlap. In town, I like the little .44Spec Bulldog for CC.