My new SR22 is my first handgun (or gun of any sort, for that matter). I think it is a great selection. I too disliked the looks of the Mark series. The SR22 is much better in that department. Field strip is VERY simple. Ergonomics are wonderful, at least for me. My wife and kids shoot it and love it, but it's still a nice little range gun for me too, as it is accurate enough to use at 25-50 yards, as you build your skills.
I haven't owned others, but I have shot others. I think the SR22 is a great choice for affordability (one of the cheaper 22's), dependability (zero FTE's so far, and a few FTF's that were likely ammo, not gun, related) and usefulness (I think it could make a decent carry pistol, if it's all you have.
My bro-in-law has the S&W22a. It is larger, with a longer barrel, so it may be more accurate, but has had FTEs, and is not a very practical carry gun due to its size.
My dad has the Beretta Neos. Again, it is larger, and has had a few more FTF/FTE's than my SR22. It also looks like it belongs in StarWars, not in my gun safe.
Perhaps the only drawback for the SR22 is the fact that a sight is easier to mount on the S&W or Neos, if that's important to you. I think the iron sights on the SR22 are just fine.