I finally talked myself into one of these and I am glad I did.
Surprisingly, I can unload the ten shot cylinder faster than the six shot. There is only a small movement from chamber to chamber so aligning with the ejection rod is almost automatic. Likewise, loading is fast since the cylinder stop lines up the chamber with the loading gate.
The sights look funky from the side, but on target they are very visible and have the same sight picture as the default single six sights. I found my single ten to be slightly more accurate than my single sixes, but I suspect this has more to do with being able to see the sights than any greater precision on the part of the machine. I think I may outfit my single sixes with these sights as well -- then I can have a proper shoot-off.
I thought not having a magnum cylinder was a big deal at first, but I cannot remember the last time I put the magnum cylinder in one of my single sixes. In the end, the lack of the magnum option didn't mean that much to me, I suppose.
The thinner "gunfighter" grips are also a nice touch. I have always preferred this type of grip, so that is just a personal preference and easy to fix if you don't like them.
I was not that excited about the single ten when I first heard about it or when I saw the pictures. But after shooting it, I am glad I have it and it will be a permanent companion in my range bag.