as noted above, obviously, safety and common sense,,,,that being said < Iknow of in cases of having to use only what you have handy ,such as varmint control, friend used 22 lr in his magnum to dispatch a coyote attacking his neighbors small dog,,,,,,,,,,,,,,
and yes, we've done it, tried it ourselves, sometimes on purpose, many others out of ignorance, forget just what cylinder is in the gun.............
in all cases, they either bulged or simply split the case....wrong ammo is wrong ammo, safety FIRST and foremost...... :wink: