Could be. Could also be too hard bullets if you are using commercially cast. they are often too hard, and don't bump up and fill the rifling, and gas blows past and blasts lead onto your bore instead of keeping the expanding gasses behind the bullet. Bevel base bullets the commercial casters make (they are easier to mold and feed better in automated machines) make it worse. That is not a real hot load, and "cowboy" hard bullets (pretty soft) work best at lower velocities. Also, is the CCI 300 a standard primer? I don't know all the numbers, but Unique (what I use exclusively) does not need or do as well with magnum primers. Can you recover any of your bullets? If you can, check the bases to see if there are signs of them being melted by hot gas blowing by.
I have had this problem with commercially cast 158 gr 38 bullets. You just about have to shoot them at magnum pressure to get them to bump up.
Just some ideas. NOT gospel