What gives one-hole groups with one rifle may not shoot worth a darn in another. For the best accuracy, fire-form any old load with match quality brass, and neck size from then on. Choose a bullet, a prime, and a powder. Then load 5 rounds at the starting load, 5 more 1/2 grain above that, 5 more another 1/2 grain higher, and so on until you reach max load.
Fire for group - don't worry about zero - you only need to be on the paper to compare group size, and the POI will be different with each load. As you're working toward max, if you encounter primer flow or cratering, or sticky extraction, QUIT and pull all the remaining bullets. Any load above that is not safe.
Choose the load with the tightest group, and record it. If it's not tight enough to satisfy you, try a different powder, different bullet, or different primer. Clever folks only change one thing at a time - if you change everything all at once, you have no idea which change made the load better (or worse). One other thing that usually (but not always) improves a rifle's performance is running a set of Tubb's Final Finish bullets through it.