Mark the cylinder notches and - with the gun confirmed empty, or using snap caps - cock and decock the weapon repeatedly, paying close attention to whether it happens predominantly on certain chambers and not others.
A question I'd have - when is it "harder" to pull the hammer? Right off the bat, or somewhere in the hammer stroke?
If it's harder right off the bat, and the test I suggested above yields consistent cylinders, then it's very likely your GP has the same issue that 4 of the new production Ruger DA's I purchased in the last two years have had: The extractor notch may need to be 'touched' just a tad, as those chambers are simply timed too early. The resistance you'd be feeling in that case is due to the cylinder binding against the stop bolt because the indexing pawl is trying to turn the cylinder before the stop has disengaged.
IF THIS IS YOUR PROBLEM, THEN THE INCORRECT THING TO DO IS TO FIRE IT UNTIL IT SMOOTHES OUT!!! Yes, it will "self correct" as your pawl and indexing ratchet mar eachother, BUT, more often, the pawl will be the part that takes the most wear. Since it's properly timed on the other chambers, when the pawl gets 'chewed down' to time properly on the improperly timed chambers, then you'll end up being a bit LATE on the chambers that used to be properly timed. Adjusting the indexing ratchet is the proper fix.