.44 mag is as big as I shoot these days, plenty for my purposes.
Here's a 7.5" Flattop .44, my favorite hunting sixgun (and was Skeeter's, so he always said). Mine is slightly non-original with a steel gripframe and ejector housing, mesquite grips - all improvements to my mind.
New Model .44 Flattop (50th Anniversary Model) with El Paso Saddlery belt and Simply Rugged Keith holster, cartridge slide, Camillus folding hunter.
Redhawk .44 was more than this song dog could digest.
Custom New Model .44 mag by John Gallagher. Started life as a NM .41 mag that was gifted to me after I'd gotten out of the .41 mag business (no hate there, just went through a time of streamlining my reloading component inventory and loading chores). Old model recessed cylinder, 5.5" Douglas barrel, white line front/Rough Country rear sight, matte blue finish. My son has claimed this one, I probably won't get it back.
Does .44 Special count as a big bore? If so here's another John Gallagher gun, .44 Special built on an old model flattop .357 frame. Qualifies as one of John Taffin's "Perfect Packin' Pistols" - I retained the alloy XR3 gripframe and ejector housing for weight savings. It does carry O-so-well.
Ok, just one more .44 Special, I promise. Smith & Wesson model 24-3. Frequently carried as a backup when hunting with a rifle as the primary weapon.