Give the .452 a shot...if no leading and accuracy are on par, you are good to go. If you do the .454...you have just negated the uniforming of the chambers...you will be right back in the same boat.
I would open that .452 up a little, if it were mine. You probably know how, but here is a link that explains how it can easily be done.
http://castboolits.gunloads.com/showthread.php?131494-how-to-open-up-a-push-through-sizing-die