I don't believe Ruger would have done a caliber change at the factory. Back in '69, I purchased a 6" Blackhawk in .41 Magnum, and I quickly became dissatisfied with the caliber choice, as ammunition supplies were difficult to find, and there was only a choice of 2 bullet weights (170 & 210 gr.) to choose from for reloading. I sent the gun to Ruger to have them re-barrel and ream the cylinders to .44 Magnum, and they returned it undone along with a letter explaining that they couldn't do work like that since the frame serial number wouldn't allow it. HOWEVER, they also provided a list of gunsmiths that specialized in caliber changes such as I requested. I decided on sending the gun to a Robert Snapp in Michigan, who re-barreled to 7-½" and reamed the cylinders for $90. You'll have to keep in mind that the original gun cost me $130 back then, and I was, and still am, extremely satisfied with the work that he did. The Sorta-Super Blackhawk shoots to 1-½" groups at 50 yards with a red dot sight, and I've shot some honker loads (25 grains of 296 under a 240 gr. bullet) out of it will no ill affects.
As an aside, when I was working up those 296 loads (around 1973), the Bushnell 2.5x scope that I had on it stripped out the front scope mount screw and lost the internal reticle while shooting them. I actually put some 26 grain loads through it, but had a hell of a time ejecting the brass, and the primers had absolutely no radius. Talk about extreme pressure! Perhaps this is a testament to the quality of the Ruger material, and I still love shooting this gun, albeit I use 24 grains of 296 under the 240 gr. bullets these days.