My first Ruger 1H was chambered in .375 H&H. I fell in love with the rifle and the cartridge.
I am left handed and a fellow left-hand shooter wanted the Ruger. He knew of someone who had a left-hand Savage 110 chambered in .22-250. We made a trade. I still have the Savage and it is a shooter.
My next .375 was a Sako left-hand Hunter. I still have that rifle too. I have since acquired another .375 H&H Ruger #1H.
Now is the story of my next Ruger #1H. I was at a gunshow and there was this fellow walking aroud with a Ruger #1H, and it had a rod in the muzzle with a sign printed with "416 Rigby." I was very interested. I wanted to pay less than he wanted. My argument was that I was the only person at the gunshow silly enough to want to shoot a .416 Rigby, so we made a deal.
All these years later, I still have the rifle. It has been fun to load for. My favorite plinking load is a 385 gr. cast-gas-check bullet loaded to 1800 fps. My stand up and take notice load is a Barnes 400 gr. X-bullet at 2600 fps. The latter had my friend Mike (a big fellow, well used to hard kicking big-bore guns) saying "s**t f**k that hurt" when he touched one off. Myself, I describe the feeling as similar to being hit in the face with a hard-thrown basketball. I backed the load off somewhat, not because it was too much for the rifle - it was just too much for me.
Now I have six big-bore #1H rifles, including a .458 Lott. One knows when the .375 goes off, but in the grander scheme, it is not earthshaking.