I've been using 4227 with 180,200 and 210 cast w/gas check. David Bradshaw has a few good loads that he has shared here as well as some other forums. Lee Martin, over at Singleactions.com has one or two other ones using something other than 4227. I've had no experience with Lil' Gun, though I do have an ample stock of it for a couple other calibers. Look at a burn chart for powders and see where it compares to 4227. Slow burning powders are the best in A Max revolver, In a contender or rifle any thing will do with few reservations, Coogs.