the average revolver losses 35-65 fps/ inch of barrel so % wise not much until ya start talking inches.
i`ve only held a 5" 1 time & to me it was a good balance of weight for the GP100.
the first deer i shot with a handgun was with a model 10 4" with standard rn ammo , our deer run `bout 130-170 on the hoof here .
given time & good shot placement theres not a deer walkin that won`t succome to a 158gr boolit.
most of my handgun kills have been no further than 30 yrds., any further i feel i owe the animal a larger caliber.
my 2 cent worth