I can't give you exactly what you want, but:
I shot Black Powder Cartridge Rifle for about fifteen years. Some of the silhouette matches had "side" pistol matches. They had requirements - fixed sights and black powder (or NMLRA BP substitute). I won a few pounds of Pyrodex Pistol powder in a match. So, I tried it in my .45 Colt Ruger Vaquero.
I loaded it just like I did Black Powder - a full case of powder that would be compressed 1/16" by seating the bullet. It worked extremely well and gave me nearly 1000 fps in long barreled (5½" and over) revolvers. It shot extremely well (under 2" at 25 yards) and I could shoot up to seventy shots or so before the cylinder started binding up from fouling. Then after a short cleaning, I could shoot another 70 shots.
It IS important to use proper bullet lubricant. I used Emmert's home mix (50% Pure Natural Beeswax, 40% Crisco, and 10% Canola Oil) but SPG works just as well (you need to use a black powder bullet lube).
My bullet was the Lyman 452644, a round flat design with a single large grease groove. It carries enough bullet lube to keep the fouling soft - this is critical both with black and PYrodex.
Using a good black powder solvent, you can clean up the revolver in five minutes or so. I only tore down my revolver about once a year. After all, the cartridge case helps to seal the fouling away from the insides of the revolver (not like the cap and ball black powder revolvers that require COMPLETE cleaning after every use).
Using cartridge revolvers with black or Pyrodex is a very practical set up, actually.
I have not tried RS but suggest it will work fine but will give a bit less performance (velocity) but also less recoil.
If I were given a bunch I would certainly load up fifty or so and try them out using the same techniques that I have outlined here.
Keep in mind that decapping your empty cases at the range and dropping them in a gallon milk jug filled with a mixture of 3/4 gallon of water and a few squirts of Dawn dishwashing liquid soap is a VERY good idea. I once ruined some .38 Special cases by failing to do this. After just a few days the powder fouling corroded them beyond recovery.
After I get home, I just simply shake up the jug, pour the dirty water off, rinse them thoroughly in VERY hot water, pour them in a colendar (do not use this for the kitchen after using for this purpose), shake the excess water off and throw them in your tumbler. I don't even wait until they dry - they polish up like new when thrown in damp. If you do not have a tumbler, then just spread out on newspaper and let them dry overnight. It IS important to decap them before you drop in the milk jug - they clean the primer pockets of corrosive materials and allow air to circulate through the cases when drying or tumbling. Tumbler grit WILL plug the flash holes but will not present a problem - the decapping pin will clear the flash holes when reloading.
FWIW
Dale53