I did some limited work along these lines many years ago when I lived in California. I got decent accuracy out to about 30 yards, give or take but when I tried for more speed, bullets became erratic and lots of keyholing.
One day while at a gun show, I came across an interesting bullet mold; a Lyman #429352, nominally a 245 gr. wadcutter in .44 caliber. I didn't even know such a thing existed.
I loaded up a few in.44 Spl. brass and the very first shot killed my chronograph. To this day I don't know ow that happened as my hold on the rest was good and my sight picture at the shot was right on. I don't even remember the load. If you have the Second Edition Lyman cast bullet manual, there is a picture on page 226, bottom row third bullet on the left.
Reading Ed Harris' article brought that long ago work to mind only I have to wonder how that 250 gr. (in my alloy) wadcutter would work at maybe 900 to 950 FPS in a .44 magnum.In my neck of the desert where one might encounter critter with teeth, claws and some with tusks, I believe I'd feel more comfortable with the bullet hole of the .44 and the bigger hole. Still should work just fine on smaller game as well. My shortest barreled .44 Mag. is a Ruger Super Blackhawk with a Blackhawk frame and Bisley hammer. Barrel length is 4 5/8". Handy to carry but brutal as hell with my full power cast bullet loads. It might be more comfortable with the Bisley grip and frame.
DAMN! As if I didn't have enough projects in the loop. Gonna have to think long and hard on this one.