Just restating what Winchester's techs have mentioned on the phone about their 380 PDX1 having a +P rating. That is their declaration and not mine. A standard pressure load from one ammo manufacture can produce higher velocities (using the same handgun & bullet) than another brand with a +P rating. Various blends of powder, primers, seating depth of bullet, and etc... (i.e. speed of slide / powder's burn rate) are all involved here.
All I'm stating is that testing of the PDX1 bullet in 380 ACP and for that matter all calibers, has generally been very good the past couple of years.
The BONDED Ranger T style PDX1 (for civilians) is an outstanding HP for an underpowered caliber like the 380, but it's +P rated so LCP owners should remember Ruger only advises standard pressure loads in their LCP. Some LCP owners are reporting good results with PDX1 on other forums after upgrading their recoil spring.
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Buffalo Bore's 100-gr. wadcutter at standard pressure is still my #1 suggestion for SD with a 380. Upgrading the LCP's recoil spring in order to use a heavy duty bonded HP like PDX1 is a second option for consideration.