The Speed Six, Service Six and Security Six family of guns are pretty much identical in strength and seems to me to be just right for the 357 round in a carry gun. It was Ruger's first double action revolver.
I believe the Wilson quote of Bill Ruger posted by 45flattop is correct. There are also some who say that the thickness of the metal of the sixes frame between the barrel threads and the cutout for the ejector rod was too thin for the comfort of Ruger engineers. Others say that production costs, not production problems led to the demise of the sixes. Those suggestions are not incompatible with each other.
It is undeniable that the ability of the sixes to handle full-power .357 magnum loads is unquestioned. Also unquestioned is that the GP100 family is stronger than the sixes. There is the thickness of the frames, but also even more thickness between the ejector rod cutout and the barrel threads because the ejector rod (and its cutout in the frame) is offset from the centerline of the cylinder. That provides much more metal between the barrel threads and the ejector rod cutout.
The GP guns are significantly heavier and bulkier than the sixes, great for hunting revolvers, not so much for duty revolvers or concealment arms.
In concealability, my 2.75" Security Six feels just about halfway between ,u SP101 and my GP100 (though it is 4", I am estimating the feature).
In strength, my lay opinion would put the strengths of the SP, GP Sixes and .357 Redhawk in this order
SP (i don't know)
Sixes (full-power service loads)
GPs full-power hunting loads, silhouette shooting, etc)
Redhawk (pushing the limits of credibility)
The lockworks of the Sixes, GPs and Redhawk are all different. The SP is very similar to the GP internals.
Lost Sheep